Determinations of Median Effective Dose (ED50) and bacterial tissue titers for test articles against infections with both gram-positive and gram-negative
pathogens, including characterized resistant strains.
Subcutaneous Abscess (Mouse)
A chronic skin infection model using either S. aureus (MRSA), S. epidermidis(MRSE), S. pyogenesor P. aeruginosa bacterial isolates.
Superficial Skin Infection Model (Mouse)
A superficial skin infection model for the determination of efficacy of topical agents using
either S. aureus, S. pyogenes, P. aeruginosa orA. baumannii individual and mixed infections.
Biofilm Catheter Implant (Mouse)
Model of device-related biofilm infection using subcutaneous S. aureus infected teflon catheter implants. Gram-negative organisms in development.
Prosthetic Joint Infection (Mouse)
Implant associated infection with a femoral pin (stainless steel) – S. aureus infection
Acute Lung Infection (Mouse)
Murine lung infections with S. aureus, S. pneumoniae, K. pneumoniae, A. baumannii, P. aeruginosa and H. influenzae using bacterial lung titers and/or survival as measured endpoints.
Acute Lung Infection (Rabbit)
Lung infections with K. pneumoniae, A. baumannii and P. aeruginosa using bacterial lung titers and/or survival as measured endpoints.
Chronic Lung Infection (Mouse)
P. aeruginosa & S. aureus (MRSA)
Central Venous Catheter Infection (Rat)
Biofilm infection of an intravascular indwelling jugular catheter with S. aureus
Granuloma Pouch (Rat / Mouse)
Infected pouch model for the simultaneous determination of penetration (levels) and
efficacy (CFU counts) of administered agents in the rat or mouse.
Helicobacter pylori Gastritis (Mouse)
Gastric infection model using H. pyloristrains with efficacy measured as CFU log reduction / relapse within the gastric mucosa.
CDAD model for the evaluation of survival / relapse, GI pharmacokinetics, fecal/cecal
bacterial titers and Tox A/B detection utilizing both susceptible and epidemic (Ribotypes
027 & 078) clinical isolates.
Neutropenic Thigh Infection Model (Mouse)
Determination of the Pharmacokinetic / Pharmacodynamic indices as related to the efficacy
of an antimicrobial agent (pharmacokinetics, dose ranging and dose fractionation studies).
Urinary Tract Infection (Mouse)
Ascending pyelonephritis model using uropathogenic E. coli bacterial isolates and the diabetic mouse UTI model with Pseudomonas aeruginosa; enumeration of the bacterial titers in kidneys, bladder and urine.
Neisseria gonorrhoeae infection (Mouse)
Infection model in ovariectomized mice
Sepsis / Inflammation (Mouse)
Murine cecal ligation and puncture model (CLP) with survival and biomarker endpoints.
Intra-abdominal Abscess Model (Rat / Mouse)
Mixed intra-abdominal infection with E. coli and B. fragilis
Antibacterial